On a large plate, whisk together the flour, salt, pepper, garlic powder, and onion powder. Dredge the pot roast in the flour mixture, coating all sides evenly.
1¼ cup (150 g) all-purpose flour, 1 tsp (5 g) table salt, 1 tsp(2 g) ground black pepper, 1 tsp (3 g) garlic powder, 1 tsp (3 g) onion powder
In a large Dutch oven or heavy-bottomed pot (6-7 quart / 5.7 - 6.6 L), heat 2 tablespoons (30 ml) of oil over medium heat until it just begins to smoke.
¼ cup (60 ml) olive oil
Place the roast in the hot pan and sear on all sides until browned.
1 4-5 lb (1.8-2.3 kg) beef chuck roast
Remove the pot roast from the pan. Add the remaining oil, then stir in the onions and celery. Cook until the onions soften, then add the garlic and cook for 30 seconds more.
2 medium yellow onions, sliced, 3 stalks celery, peeled and quartered, 4 cloves garlic, minced or pressed
Pour in the red wine to deglaze the pan, using a wooden spoon to scrape up the browned bits from the bottom.
1 cup (240 ml) dry red wine
Return the meat to the pan and top with carrots and beef broth.
5 medium carrots peeled and quartered, 2¼ cups (18 oz / 530 ml) low-sodium beef broth
Cover the pot and reduce the heat to medium-low. Cook for 1 hour.
Add the potatoes to the pot, cover, and continue simmering until the beef is tender, about 1 to 2 more hours. The roast is done when two forks can easily pull the meat apart. Cooking times may vary depending on the temperature of the meat, your stove, and the size of the roast.
1 bag (24 oz / 680 g) baby potatoes